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BrainStorm Cell Therapeutics Inc., a leader in developing innovative autologous cellular therapies for debilitating neurodegenerative diseases, announced that the Israel Patent Office has granted an additional patent titled “Methods of Generating Mesenchymal Stem Cells which Secrete Neurotrophic Factors.” The allowed claims cover the method of manufacturing the cells, the cells generated according to the method of manufacturing, and the use of the cells for preparation of a therapy for treating a disease (including a neurodegenerative disease, a neurological and an immune disease).
“Our intellectual property estate for NurOwn technology platform continues to grow substantially as evidenced by this new patent granted by the Israel Patent Office which is a welcome addition to our IP portfolio. This patent covers NurOwn (MSC-NTF cells) and its manufacturing process developed by Brainstorm’s scientists as well as the use of NurOwn for the treatment of neurodegenerative diseases, an acute unmet need” commented BrainStorm’s CEO Chaim Lebovits. “Having an Israel patented product and manufacturing process will increase our ability to treat patients in desperate need of options for these debilitating diseases in Israel. We expect that additional patents owned or licensed exclusively by BrainStorm will be awarded this year and in future years, thereby broadening the utility of NurOwn in global markets across the world.”
About NurOwn
NurOwn® (autologous MSC-NTF) cells are an innovative cellular technology platform that targets disease pathways known to be important in neurodegenerative disorders. MSC-NTF cells are produced from autologous, bone marrow-derived mesenchymal stem cells (MSCs) that have been expanded and differentiated under patented and scalable manufacturing processes that induce the cells to secrete high levels of neurotrophic factors and immunomodulatory cytokines. Autologous MSC-NTF cells can effectively deliver these factors directly to the site of damage to elicit a desired biological effect and ultimately slow or stabilize disease progression. BrainStorm is actively enrolling a Phase 3 pivotal trial of autologous MSC-NTF cells for the treatment of amyotrophic lateral sclerosis (ALS) (NCT03280056). BrainStorm also recently received U.S. FDA acceptance to initiate a Phase 2 open-label multicenter trial in progressive Multiple Sclerosis (MS) and plans to start enrollment in early 2019 (NCT03799718).
Key Facts