Tuesday, November 19, 2019
DrugName : CF-602
Can-Fite BioPharma Ltd., a biotechnology company with a pipeline of proprietary small molecule drugs that address inflammatory, cancer and liver diseases, announced it has been granted patents in Canada, South Korea, and Israel for its patent titled, “A3 adenosine receptor ligands for use in treatment of a sexual dysfunction” for its drug candidate CF602. Patents were also issued in the U.S., Australia, China, Hong Kong, and Japan over the past few years.
“CF602 has a unique mechanism of action that makes it suitable to potentially treat sexual dysfunction safely in patients with diabetes mellitus. This is a clear and unmet need in the market today, as the leading sexual dysfunction drugs can be contraindicated for diabetics. We are now actively looking for and evaluating potential strategic partners that may in-license and develop CF602 in this indication,” stated Can-Fite CEO Dr. Pnina Fishman. “Can-Fite remains highly focused on our advanced stage drugs, Namodenoson and Piclidenoson currently in Phase II and Phase III studies.”
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Preclinical studies in rats with diabetes mellitus show that CF602 has a mechanism of action similar to sildenafil (Viagra®), with CF602 demonstrating effects on erection superior to that demonstrated by sildenafil in animal studies. In a diabetic rat model, CF602 demonstrated a 188% and 250% increase in penile intracavernous pressure (ICP) for rats treated with CF602 for 1 day and for 5 days, respectively, as compared to placebo. CF602 demonstrated statistically significant full recovery from erectile dysfunction after a single dose treatment in a diabetic rat model.
Grand View Research Inc. estimates the value of the erectile dysfunction therapeutic market will reach approximately $3.2 billion by 2022. According to the American Diabetes Association, approximately 30 million Americans have diabetes mellitus in the U.S. It is estimated that 35-75% of men with diabetes mellitus suffer from erectile dysfunction.
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